4xs2 A 2.73 BS01 42P A 1 V200 A211 K213 Y262 Y264 M265 G268 S269 A315 L318 D329 V36 A47 K49 Y93 Y95 M96 G99 S100 A146 L149 D160 D311 K313 A315 N316 D329 T351 D142 K144 A146 N147 D160 T178 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 -logKd/Ki=5.82, IC50=1.52uM Q9NWZ3 25870132 501 TRFHSFSFYELKNVTNNFDERPISVNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4xs2 B 2.73 BS01 42P B 1 M192 A211 K213 Y262 Y264 M265 G268 S269 A315 L318 D329 M30 A49 K51 Y91 Y93 M94 G97 S98 A144 L147 D158 D311 K313 A315 N316 D329 T351 D140 K142 A144 N145 D158 T173 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25870132 501 SDTRFHSFSFYELKNVTNNFDERPISVNKMGEGGFGVVYKGYVNNTTVAVKKLALKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4xs2 C 2.73 BS01 42P C 1 M192 A211 K213 Y262 M265 P266 G268 A315 L318 D329 M29 A48 K50 Y90 M93 P94 G96 A143 L146 D157 D311 K313 A315 N316 D329 T351 D139 K141 A143 N144 D157 T175 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25870132 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLITTEELKQQFDQEIKVMAKCQHENLVELLGFSSLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 4xs2 D 2.73 BS01 42P D 1 M192 G193 E194 A211 K213 Y262 Y264 M265 P266 G268 S269 A315 L318 D329 M26 G27 E28 A43 K45 Y88 Y90 M91 P92 G94 S95 A141 L144 D155 D311 K313 A315 N316 D329 T351 D137 K139 A141 N142 D155 T172 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 Q9NWZ3 25870132 501 RFHSFSFYELKNVTNNFDERPIGNKMGEGGVVYKGYVNNTTVAVKKLAAEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA