4x8g A 3.29 BS01 CA A 1 E353 F407 L410 E411 E313 F352 L355 E356 D350 H471 D473 A645 D310 H416 D418 A588 3.5.3.15 0004668,0005509,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0006338,0016787,0019827,0032991,0036211,0042802,0043687,0045087,0046872,0140794,0140795,0140796,0140797,0140798 Q9UM07 25622091 701 QGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIASTWPLDPGVEVTLTMKVASGSTGDQKVQISYYPVKALLYLTGVEISLCADITRTGKVKPTAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACFENEDFLKSVTTLAMKAKCKLTIQDEMEIGYIQAPHKTLPVVFDSPRKRVMGPDFGYVTRISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIGEVHAGTNVRRKPFSFKWWNMVP 4x8g A 3.29 BS02 CA A 2 N153 D155 D157 D165 D176 D179 N133 D135 D137 D145 D156 D159 D350 H471 D473 A645 D310 H416 D418 A588 3.5.3.15 0004668,0005509,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0006338,0016787,0019827,0032991,0036211,0042802,0043687,0045087,0046872,0140794,0140795,0140796,0140797,0140798 Q9UM07 25622091 702 QGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIASTWPLDPGVEVTLTMKVASGSTGDQKVQISYYPVKALLYLTGVEISLCADITRTGKVKPTAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACFENEDFLKSVTTLAMKAKCKLTIQDEMEIGYIQAPHKTLPVVFDSPRKRVMGPDFGYVTRISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIGEVHAGTNVRRKPFSFKWWNMVP 4x8g A 3.29 BS03 CA A 3 D157 D179 K362 D388 D137 D159 K322 D339 D350 H471 D473 A645 D310 H416 D418 A588 3.5.3.15 0004668,0005509,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0006338,0016787,0019827,0032991,0036211,0042802,0043687,0045087,0046872,0140794,0140795,0140796,0140797,0140798 Q9UM07 25622091 703 QGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIASTWPLDPGVEVTLTMKVASGSTGDQKVQISYYPVKALLYLTGVEISLCADITRTGKVKPTAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACFENEDFLKSVTTLAMKAKCKLTIQDEMEIGYIQAPHKTLPVVFDSPRKRVMGPDFGYVTRISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIGEVHAGTNVRRKPFSFKWWNMVP 4x8g A 3.29 BS04 CA A 4 D165 D168 E170 D145 D148 E150 D350 H471 D473 A645 D310 H416 D418 A588 3.5.3.15 0004668,0005509,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0006338,0016787,0019827,0032991,0036211,0042802,0043687,0045087,0046872,0140794,0140795,0140796,0140797,0140798 Q9UM07 25622091 704 QGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIASTWPLDPGVEVTLTMKVASGSTGDQKVQISYYPVKALLYLTGVEISLCADITRTGKVKPTAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACFENEDFLKSVTTLAMKAKCKLTIQDEMEIGYIQAPHKTLPVVFDSPRKRVMGPDFGYVTRISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIGEVHAGTNVRRKPFSFKWWNMVP 4x8g A 3.29 BS05 3Z0 A 1 H471 D473 E474 A581 F582 F583 P584 N585 N588 F634 V643 H416 D418 E419 A526 F527 F528 P529 N530 N533 F579 V586 D350 H471 D473 A645 D310 H416 D418 A588 3.5.3.15 0004668,0005509,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0006338,0016787,0019827,0032991,0036211,0042802,0043687,0045087,0046872,0140794,0140795,0140796,0140797,0140798 -logKd/Ki=6.00, IC50=1uM Q9UM07 25622091 705 QGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIASTWPLDPGVEVTLTMKVASGSTGDQKVQISYYPVKALLYLTGVEISLCADITRTGKVKPTAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACFENEDFLKSVTTLAMKAKCKLTIQDEMEIGYIQAPHKTLPVVFDSPRKRVMGPDFGYVTRISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIGEVHAGTNVRRKPFSFKWWNMVP