4x0u A 1.95 BS01 3W9 A 1 F168 V172 C302 F166 V170 C299 N167 K190 E268 C302 E399 N165 K188 E266 C299 E396 1.2.1.3,1.2.1.31,1.2.1.8 0004029,0004043,0005515,0005634,0005737,0005739,0005759,0005829,0006081,0007605,0008802,0016491,0016620,0019285,0042426,0042802,0070062 -logKd/Ki=7.40, Ki=0.04uM P49419 25554827 601 TLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNISDAWKQYMRRSTCTINYQGIKFQ 4x0u B 1.95 BS01 3W9 B 1 F168 A171 C302 F468 F166 A169 C300 F457 N167 K190 E268 C302 E399 E479 N165 K188 E266 C300 E397 E464 1.2.1.3,1.2.1.31,1.2.1.8 0004029,0004043,0005515,0005634,0005737,0005739,0005759,0005829,0006081,0007605,0008802,0016491,0016620,0019285,0042426,0042802,0070062 P49419 25554827 601 TLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTAFGGEKHTESGSDAWKQYMRRSTCTINYS 4x0u C 1.95 BS01 3W9 C 1 F168 V172 C302 F166 V170 C299 N167 K190 E268 C302 E399 N165 K188 E266 C299 E396 1.2.1.3,1.2.1.31,1.2.1.8 0004029,0004043,0005515,0005634,0005737,0005739,0005759,0005829,0006081,0007605,0008802,0016491,0016620,0019285,0042426,0042802,0070062 P49419 25554827 601 TLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ 4x0u D 1.95 BS01 3W9 D 1 F168 A171 V172 C302 F468 H473 F166 A169 V170 C300 F456 H461 N167 K190 E268 C302 E399 E479 N165 K188 E266 C300 E397 E467 1.2.1.3,1.2.1.31,1.2.1.8 0004029,0004043,0005515,0005634,0005737,0005739,0005759,0005829,0006081,0007605,0008802,0016491,0016620,0019285,0042426,0042802,0070062 P49419 25554827 601 TLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTFGGEKHTGGGRESGSDAWKQYMRRSTCTINYS 4x0u D 1.95 BS02 MG D 1 E121 D124 E119 D122 N167 K190 E268 C302 E399 E479 N165 K188 E266 C300 E397 E467 1.2.1.3,1.2.1.31,1.2.1.8 0004029,0004043,0005515,0005634,0005737,0005739,0005759,0005829,0006081,0007605,0008802,0016491,0016620,0019285,0042426,0042802,0070062 P49419 25554827 602 TLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTFGGEKHTGGGRESGSDAWKQYMRRSTCTINYS