4wzv A 1.65 BS01 E40 A 1 L187 L188 A189 H190 A191 H226 E227 H230 D235 H236 L243 Y245 P246 M247 Y248 L76 L77 A78 H79 A80 H115 E116 H119 D124 H125 L132 Y134 P135 M136 Y137 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 ic50=0.43nM -logKd/Ki=9.37, IC50=0.43nM IC50=0.430000nM P14780 26263024 301 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv A 1.65 BS02 ZN A 1 H226 H230 H236 H115 H119 H125 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 302 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv A 1.65 BS03 ZN A 2 H175 D177 H190 H203 H64 D66 H79 H92 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 303 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv A 1.65 BS04 CA A 1 D165 G197 Q199 D201 D54 G86 Q88 D90 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 304 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv A 1.65 BS05 CA A 2 D131 D206 E208 D20 D95 E97 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 305 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv A 1.65 BS06 CA A 3 D182 G183 D185 L187 D205 E208 D71 G72 D74 L76 D94 E97 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 306 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv A 1.65 BS07 E40 B 1 Y245 P246 Y134 P135 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 ic50=0.43nM -logKd/Ki=9.37, IC50=0.43nM IC50=0.430000nM P14780 26263024 301 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS01 E40 A 1 Y245 P246 Y134 P135 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 ic50=0.43nM IC50=0.430000nM P14780 26263024 301 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS02 E40 B 1 L187 A189 H190 A191 H226 E227 H230 H236 L243 Y245 P246 M247 Y248 L76 A78 H79 A80 H115 E116 H119 H125 L132 Y134 P135 M136 Y137 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 ic50=0.43nM IC50=0.430000nM P14780 26263024 301 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS03 ZN B 1 H226 H230 H236 H115 H119 H125 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 302 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS04 ZN B 2 H175 D177 H190 H203 H64 D66 H79 H92 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 303 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS05 CA B 1 D165 G197 Q199 D201 D54 G86 Q88 D90 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 304 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS06 CA B 2 D131 D206 E208 D20 D95 E97 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 305 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG 4wzv B 1.65 BS07 CA B 3 D182 G183 D185 L187 D205 E208 D71 G72 D74 L76 D94 E97 H226 E227 H230 H236 H115 E116 H119 H125 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 26263024 306 GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYG