4wq2 A 1.64 BS01 3SU A 1 L124 V127 H131 Q175 L29 V32 H36 Q80 F164 G187 I189 F69 G92 I94 ? 0005509 ic50=0.5uM -logKd/Ki=6.30, IC50=0.5uM P04632 28757975 301 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 A 1.64 BS02 CA A 1 A109 D112 E114 E119 A14 D17 E19 E24 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 302 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 A 1.64 BS03 CA A 2 D152 D154 T156 K158 E163 D57 D59 T61 K63 E68 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 303 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 A 1.64 BS04 CA A 3 D182 D184 S186 T188 E193 D87 D89 S91 T93 E98 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 304 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 A 1.64 BS05 CA A 4 D137 D225 D227 N228 D42 D130 D132 N133 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 305 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 B 1.64 BS01 3SU B 1 V127 Q175 V32 Q80 F164 G187 I189 F69 G92 I94 ? 0005509 ic50=0.5uM P04632 28757975 301 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 B 1.64 BS02 CA B 1 A109 D112 E114 E119 A14 D17 E19 E24 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 302 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 B 1.64 BS03 CA B 2 D152 D154 T156 K158 E163 D57 D59 T61 K63 E68 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 303 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 B 1.64 BS04 CA B 3 D182 D184 S186 T188 E193 D87 D89 S91 T93 E98 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 304 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS 4wq2 B 1.64 BS05 CA B 4 D137 D225 D227 N228 D42 D130 D132 N133 F164 G187 I189 F69 G92 I94 ? 0005509 P04632 28757975 305 EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS