4wnt A 2.6 BS01 HEM A 1 R101 V119 F120 W128 R132 A305 T309 H376 P435 F436 S437 R441 C443 L444 G445 L448 R61 V79 F80 W88 R92 A265 T269 H336 P395 F396 S397 R401 C403 L404 G405 L408 T309 F436 C443 T269 F396 C403 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 P10635 25555909 601 GKLPPGPLPDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 4wnt A 2.6 BS02 AJN A 1 L110 F120 A209 L213 E216 Q244 F247 D301 S304 A305 F483 L70 F80 A169 L173 E176 Q204 F207 D261 S264 A265 F443 T309 F436 C443 T269 F396 C403 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 Ki=4.6nM P10635 25555909 602 GKLPPGPLPDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 4wnt A 2.6 BS03 ZN A 1 H258 D270 E273 H218 D230 E233 T309 F436 C443 T269 F396 C403 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 P10635 25555909 603 GKLPPGPLPDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 4wnt A 2.6 BS04 ZN A 2 D422 H426 D382 H386 T309 F436 C443 T269 F396 C403 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 P10635 25555909 604 GKLPPGPLPDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 4wnt B 2.6 BS01 HEM B 1 R101 F120 R132 A305 G306 T309 V374 H376 P435 F436 S437 R441 C443 L444 G445 R59 F78 R90 A263 G264 T267 V332 H334 P393 F394 S395 R399 C401 L402 G403 T309 F436 C443 T267 F394 C401 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 P10635 25555909 601 GKLPPGPLPQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 4wnt B 2.6 BS02 AJN B 1 L110 F120 A209 L213 E216 Q244 F247 A300 D301 S304 A305 F483 L68 F78 A167 L171 E174 Q202 F205 A258 D259 S262 A263 F441 T309 F436 C443 T267 F394 C401 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 Ki=4.6nM P10635 25555909 602 GKLPPGPLPQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 4wnt B 2.6 BS03 ZN B 1 H258 D270 E273 H216 D228 E231 T309 F436 C443 T267 F394 C401 1.14.14.- 0004497,0005506,0005737,0005739,0005783,0005789,0006631,0006805,0008202,0008203,0008210,0009804,0009820,0009822,0016020,0016098,0016491,0016705,0016712,0019369,0020037,0033076,0042178,0042572,0042759,0043231,0046872,0051100,0062187,0062188,0062189,0070989,0090350 P10635 25555909 603 GKLPPGPLPQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR