4wki A 1.6 BS01 ZN A 1 H361 H365 H371 H142 H146 H152 3.4.24.82 0004222,0006508,0008237 O75173 25415648 501 SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wki A 1.6 BS02 CA A 1 E221 D304 D311 C423 D426 E7 D85 D92 C202 D205 3.4.24.82 0004222,0006508,0008237 O75173 25415648 502 SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wki A 1.6 BS03 CA A 2 E221 D304 D426 E7 D85 D205 3.4.24.82 0004222,0006508,0008237 O75173 25415648 503 SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wki A 1.6 BS04 CA A 3 D320 L321 C327 T329 E349 D101 L102 C108 T110 E130 3.4.24.82 0004222,0006508,0008237 O75173 25415648 504 SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP 4wki A 1.6 BS05 3PW A 1 T329 L330 G331 H361 E362 H371 V390 A392 P393 V394 M395 T110 L111 G112 H142 E143 H152 V169 A171 P172 V173 M174 3.4.24.82 0004222,0006508,0008237 ic50=5nM -logKd/Ki=8.30, IC50=5nM IC50=3.0nM O75173 25415648 506 SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLP