4wk7 A 1.24 BS01 ZN A 1 H361 H365 H371 H140 H144 H150 3.4.24.82 0004222,0006508,0008237 O75173 25415648 501 SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL 4wk7 A 1.24 BS02 CA A 1 E221 D304 D311 C423 D426 E5 D83 D90 C200 D203 3.4.24.82 0004222,0006508,0008237 O75173 25415648 502 SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL 4wk7 A 1.24 BS03 CA A 2 E221 D304 D426 E5 D83 D203 3.4.24.82 0004222,0006508,0008237 O75173 25415648 503 SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL 4wk7 A 1.24 BS04 CA A 3 D320 L321 C327 T329 E349 D99 L100 C106 T108 E128 3.4.24.82 0004222,0006508,0008237 O75173 25415648 504 SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL 4wk7 A 1.24 BS05 3PQ A 1 T329 L330 G331 F357 H361 E362 H371 V390 A392 P393 V394 M395 T108 L109 G110 F136 H140 E141 H150 V167 A169 P170 V171 M172 3.4.24.82 0004222,0006508,0008237 ic50=74nM -logKd/Ki=7.13, IC50=74nM IC50=74nM O75173 25415648 505 SRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL