4wbo A 2.81 BS01 ANW A 1 L193 A214 M267 L321 A478 L166 A187 M240 L294 A451 D314 K316 E318 N319 D332 A341 T352 D287 K289 E291 N292 D305 A314 T325 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 -logKd/Ki=4.20, IC50=63.10uM P28327 25340299 601 PASRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP 4wbo B 2.81 BS01 ANW B 1 L193 M267 N268 L321 A478 L164 M238 N239 L292 A449 D314 K316 E318 N319 D332 A341 T352 D285 K287 E289 N290 D303 A312 T323 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 25340299 601 SRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP 4wbo C 2.81 BS01 ANW C 1 L193 A214 M267 N268 L321 L163 A184 M237 N238 L291 D314 K316 E318 N319 D332 A341 T352 D284 K286 E288 N289 D302 A311 T322 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 25340299 601 RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVW 4wbo D 2.81 BS01 ANW D 1 L193 A214 M264 T265 M267 L321 Y477 A478 L159 A180 M230 T231 M233 L287 Y443 A444 D314 K316 E318 N319 D332 A341 T352 D280 K282 E284 N285 D298 A307 T318 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 25340299 601 SRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARALFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNIQDVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVW