4v0u A 7.88 BS01 LAB A 1 G15 L16 P32 Q59 Y69 D157 R183 T186 R206 E207 R210 G15 L16 P32 Q48 Y58 D146 R172 T175 R195 E196 R199 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 25774600 1376 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u A 7.88 BS02 ATP A 1 G13 S14 G15 L16 K18 G156 D157 G158 V159 R210 K213 E214 G302 M305 Y306 K336 G13 S14 G15 L16 K18 G145 D146 G147 V148 R199 K202 E203 G291 M294 Y295 K325 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25774600 1377 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u B 7.88 BS01 LAB B 1 G15 L16 P32 Q59 Y69 D157 R183 T186 R206 E207 R210 G15 L16 P32 Q48 Y58 D146 R172 T175 R195 E196 R199 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 25774600 1376 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u B 7.88 BS02 ATP B 1 G13 S14 G15 L16 K18 G156 D157 G158 V159 G182 R210 K213 E214 G302 M305 Y306 K336 G13 S14 G15 L16 K18 G145 D146 G147 V148 G171 R199 K202 E203 G291 M294 Y295 K325 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25774600 1377 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u C 7.88 BS01 LAB C 1 G15 L16 P32 Q59 Y69 D157 R183 T186 R206 E207 R210 G15 L16 P32 Q48 Y58 D146 R172 T175 R195 E196 R199 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 25774600 1376 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u C 7.88 BS02 ATP C 1 G13 S14 G15 L16 K18 G156 D157 G158 V159 G182 R210 K213 E214 G302 M305 Y306 K336 G13 S14 G15 L16 K18 G145 D146 G147 V148 G171 R199 K202 E203 G291 M294 Y295 K325 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25774600 1377 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u D 7.88 BS01 peptide E 0 Q68 D71 R74 Y78 D242 Y255 F257 P270 N271 D277 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299 E300 Q62 D65 R68 Y72 D236 Y249 F251 P264 N265 D271 E281 L283 M284 C285 S286 F287 Q288 I289 L290 K291 P292 A293 E294 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 639 ~ 658 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u D 7.88 BS02 MN D 1 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1301 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u D 7.88 BS03 MN D 2 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1302 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u F 7.88 BS01 peptide G 0 Q68 D71 R74 Y78 D242 F257 P270 N271 D277 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299 E300 Q62 D65 R68 Y72 D236 F251 P264 N265 D271 E281 L283 M284 C285 S286 F287 Q288 I289 L290 K291 P292 A293 E294 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 639 ~ 658 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u F 7.88 BS02 MN F 1 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1301 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u F 7.88 BS03 MN F 2 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1302 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u H 7.88 BS01 peptide I 0 Q68 D71 R74 Y78 D242 F257 P270 N271 D277 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299 E300 Q62 D65 R68 Y72 D236 F251 P264 N265 D271 E281 L283 M284 C285 S286 F287 Q288 I289 L290 K291 P292 A293 E294 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 639 ~ 658 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u H 7.88 BS02 MN H 1 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1301 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u H 7.88 BS03 MN H 2 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1302 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u J 7.88 BS01 peptide K 0 Q68 D71 R74 Y78 D242 F257 P270 N271 D277 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299 E300 Q62 D65 R68 Y72 D236 F251 P264 N265 D271 E281 L283 M284 C285 S286 F287 Q288 I289 L290 K291 P292 A293 E294 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 639 ~ 658 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u J 7.88 BS02 MN J 1 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1301 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u J 7.88 BS03 MN J 2 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1302 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u L 7.88 BS01 LAB L 1 G15 L16 P32 Q59 Y69 D157 R183 T186 R206 E207 R210 G15 L16 P32 Q48 Y58 D146 R172 T175 R195 E196 R199 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 25774600 1376 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u L 7.88 BS02 ATP L 1 G13 S14 G15 L16 K18 G156 D157 G158 V159 G182 R210 K213 E214 G302 M305 Y306 K336 G13 S14 G15 L16 K18 G145 D146 G147 V148 G171 R199 K202 E203 G291 M294 Y295 K325 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25774600 1377 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u M 7.88 BS01 LAB M 1 G15 L16 P32 Q59 Y69 D157 R183 T186 R206 E207 R210 G15 L16 P32 Q48 Y58 D146 R172 T175 R195 E196 R199 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 IC50=8470nM P68135 25774600 1376 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u M 7.88 BS02 ATP M 1 G13 S14 G15 L16 K18 G156 D157 G158 V159 R210 K213 E214 G302 M305 Y306 K336 G13 S14 G15 L16 K18 G145 D146 G147 V148 R199 K202 E203 G291 M294 Y295 K325 3.6.4.- 0000287,0001725,0003785,0005509,0005515,0005523,0005524,0005737,0005856,0005865,0005884,0010628,0016787,0019904,0030027,0030041,0030175,0030240,0031013,0031432,0031941,0032036,0032432,0042802,0044297,0048306,0048741,0051017,0090131,0098723,0140660 P68135 25774600 1377 DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 4v0u N 7.88 BS01 peptide O 0 Q68 D71 R74 Y78 D242 F257 P270 N271 D277 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299 E300 Q62 D65 R68 Y72 D236 F251 P264 N265 D271 E281 L283 M284 C285 S286 F287 Q288 I289 L290 K291 P292 A293 E294 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 639 ~ 658 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u N 7.88 BS02 MN N 1 D64 H66 D92 D58 H60 D86 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1301 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE 4v0u N 7.88 BS03 MN N 2 D92 N124 H173 H248 D86 N118 H167 H242 D64 H66 D92 D95 R96 N124 H125 H173 R221 H248 D58 H60 D86 D89 R90 N118 H119 H167 R215 H242 3.1.3.16 0000775,0000776,0000781,0001824,0004721,0004722,0005515,0005521,0005634,0005654,0005694,0005730,0005737,0005739,0005741,0005815,0005856,0005977,0006470,0007283,0008157,0016607,0016787,0016791,0017018,0019901,0019903,0019904,0030182,0030496,0032154,0032922,0032991,0042752,0043153,0043197,0044877,0046822,0046872,0048511,0051301,0060252,0072357,0098793,0098794,0098978 P63087 25774600 1302 LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE