4uw1 A 3.37 BS01 ZN A 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 A 3.37 BS02 92R A 1 H1184 G1185 Y1203 Y1213 A1215 Y1224 E1291 H80 G81 Y99 Y109 A111 Y120 E187 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=7.72, IC50=19nM O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 B 3.37 BS01 ZN B 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 B 3.37 BS02 92R B 1 H1184 G1185 H1201 Y1203 Y1213 A1215 S1221 Y1224 E1291 H80 G81 H97 Y99 Y109 A111 S117 Y120 E187 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 C 3.37 BS01 ZN C 1 C1234 H1237 C1242 C1245 C125 H128 C133 C136 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYGGFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 4uw1 C 3.37 BS02 92R C 1 H1184 G1185 S1186 Y1203 Y1213 F1214 A1215 Y1224 E1291 H77 G78 S79 Y96 Y104 F105 A106 Y115 E182 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYGGFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 4uw1 D 3.37 BS01 ZN D 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEA 4uw1 D 3.37 BS02 92R D 1 H1184 G1185 Y1203 Y1213 F1214 A1215 Y1224 E1291 H80 G81 Y99 Y109 F110 A111 Y120 E187 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEA 4uw1 E 3.37 BS01 ZN E 1 C1234 H1237 C1242 C130 H133 C138 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSLAYAEYVIYRGEQAYPEYLITYQIMKPE 4uw1 E 3.37 BS02 92R E 1 H1184 G1185 S1186 H1201 Y1203 Y1213 A1215 K1220 S1221 Y1224 E1291 H80 G81 S82 H97 Y99 Y109 A111 K116 S117 Y120 E184 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSLAYAEYVIYRGEQAYPEYLITYQIMKPE 4uw1 F 3.37 BS01 ZN F 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 F 3.37 BS02 92R F 1 H1184 G1185 S1186 H1201 Y1203 Y1213 A1215 S1221 Y1224 E1291 H80 G81 S82 H97 Y99 Y109 A111 S117 Y120 E187 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 G 3.37 BS01 ZN G 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 G 3.37 BS02 92R G 1 H1184 G1185 S1186 Y1203 Y1213 A1215 S1221 Y1224 E1291 H80 G81 S82 Y99 Y109 A111 S117 Y120 E187 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKP 4uw1 H 3.37 BS01 ZN H 1 C1234 H1237 C1242 C1245 C130 H133 C138 C141 2.4.2.-,2.4.2.30 0003950 O95271 2000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE 4uw1 H 3.37 BS02 92R H 1 H1184 G1185 Y1203 Y1213 S1221 Y1224 E1291 H80 G81 Y99 Y109 S117 Y120 E187 2.4.2.-,2.4.2.30 0003950 O95271 3000 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE