4u1b A 1.89 BS01 CO A 1 D240 H303 T334 E336 E367 D151 H214 T245 E247 E278 D229 D240 H303 H310 E336 E367 D140 D151 H214 H221 E247 E278 3.4.11.18 0006508,0070006 P53582 25699713 401 YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS 4u1b A 1.89 BS02 CO A 2 D229 D240 E367 D140 D151 E278 D229 D240 H303 H310 E336 E367 D140 D151 H214 H221 E247 E278 3.4.11.18 0006508,0070006 P53582 25699713 402 YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS 4u1b A 1.89 BS03 Q08 A 1 F198 C203 H212 D229 D240 H303 H310 E336 E367 F109 C114 H123 D140 D151 H214 H221 E247 E278 D229 D240 H303 H310 E336 E367 D140 D151 H214 H221 E247 E278 3.4.11.18 0006508,0070006 Ki=4.9uM -logKd/Ki=5.31, Ki=4.9uM Ki=4900nM P53582 25699713 404 YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS