4tmr A 2.7 BS01 PLG A 1 S34 S100 G101 S102 H129 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 25785478 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr A 2.7 BS02 99S A 1 L124 G128 H129 L130 V141 T183 N354 K355 N356 T357 C364 R371 L124 G128 H129 L130 V141 T183 N354 K355 N356 T357 C364 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=7.22, IC50=60nM A5K8L9 25785478 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr A 2.7 BS03 99S B 1 E56 Y63 Y64 E56 Y63 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=7.22, IC50=60nM A5K8L9 25785478 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr B 2.7 BS01 99S A 1 E56 Y63 Y64 E56 Y63 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=7.22, IC50=60nM A5K8L9 25785478 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr B 2.7 BS02 PLG B 1 S34 S100 G101 S102 H129 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 25785478 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr B 2.7 BS03 99S B 1 L124 G128 H129 L130 V141 T183 N356 C364 R371 L124 G128 H129 L130 V141 T183 N356 C364 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=7.22, IC50=60nM A5K8L9 25785478 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr C 2.7 BS01 PLG C 1 S34 S100 G101 S102 H129 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 25785478 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tmr C 2.7 BS02 99S C 1 L124 G128 H129 L130 V141 T183 N354 K355 N356 C364 R371 L124 G128 H129 L130 V141 T183 N354 K355 N356 C364 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 25785478 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP