4tkf A 2.6 BS01 ZN A 1 C1081 H1084 C1089 C1092 C120 H123 C128 C131 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf A 2.6 BS02 33C A 1 H1031 S1033 F1035 A1038 G1043 F1044 D1045 H1048 Y1050 I1059 Y1060 Y1071 H70 S72 F74 A77 G82 F83 D84 H87 Y89 I98 Y99 Y110 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=6.55, IC50=0.285uM IC50=31nM Q9H2K2 25286857 1202 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf A 2.6 BS03 3AB A 1 H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H70 G71 Y99 F100 A101 K106 S107 Y110 E177 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf B 2.6 BS01 ZN B 1 C1081 H1084 C1089 C1092 C125 H128 C133 C136 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 FQGSPDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf B 2.6 BS02 33C B 1 H1031 S1033 F1035 A1038 I1039 G1043 F1044 D1045 H1048 Y1060 Y1071 I1075 H75 S77 F79 A82 I83 G87 F88 D89 H92 Y104 Y115 I119 2.4.2.-,2.4.2.30 0003950 IC50=31nM Q9H2K2 25286857 1202 FQGSPDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf C 2.6 BS01 ZN C 1 C1081 H1084 C1089 C1092 C129 H132 C137 C140 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf C 2.6 BS02 33C C 1 H1031 F1035 A1038 G1043 F1044 D1045 H1048 I1059 Y1060 Y1071 I1075 H79 F83 A86 G91 F92 D93 H96 I107 Y108 Y119 I123 2.4.2.-,2.4.2.30 0003950 IC50=31nM Q9H2K2 25286857 1202 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf C 2.6 BS03 3AB C 1 H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H79 G80 Y108 F109 A110 K115 S116 Y119 E186 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf D 2.6 BS01 ZN D 1 C1081 H1084 C1089 C1092 C117 H120 C125 C128 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 FQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRAEYVIYRGEQAYPEYLITYQIMRP 4tkf D 2.6 BS02 33C D 1 S1033 F1035 A1038 G1043 F1044 D1045 H1048 I1059 Y1060 Y1071 S69 F71 A74 G79 F80 D81 H84 I95 Y96 Y107 2.4.2.-,2.4.2.30 0003950 IC50=31nM Q9H2K2 25286857 1202 FQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRAEYVIYRGEQAYPEYLITYQIMRP