4std A 2.15 BS01 BFS A 1 Y30 Y50 V75 L76 V108 S129 I151 F158 F162 G165 Y22 Y42 V67 L68 V100 S121 I143 F150 F154 G157 Y30 D31 Y50 H85 H110 Y22 D23 Y42 H77 H102 4.2.1.94 0005575,0005768,0006582,0016829,0030411,0042438,0046872 Ki=47pM -logKd/Ki=10.33, Ki=47pM Ki=47nM P56221 10382670 173 GEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLWEAMPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRVPHQRYKDTTMKEVTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDFDRIFEDGRETFGDK 4std B 2.15 BS01 BFS B 1 Y30 Y50 V75 L76 V108 S129 N131 P149 F162 G165 Y22 Y42 V67 L68 V100 S121 N123 P141 F154 G157 Y30 D31 Y50 H85 H110 Y22 D23 Y42 H77 H102 4.2.1.94 0005575,0005768,0006582,0016829,0030411,0042438,0046872 Ki=47pM -logKd/Ki=10.33, Ki=47pM Ki=47nM P56221 10382670 174 GEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLWEAMPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRVPHQRYKDTTMKEVTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDFDRIFEDGRETFGDK 4std C 2.15 BS01 BFS C 1 Y30 Y50 F53 V75 L76 V108 N131 F158 F162 G165 Y22 Y42 F45 V67 L68 V100 N123 F150 F154 G157 Y30 D31 Y50 H85 H110 Y22 D23 Y42 H77 H102 4.2.1.94 0005575,0005768,0006582,0016829,0030411,0042438,0046872 Ki=47pM Ki=47nM P56221 10382670 175 GEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLWEAMPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRVPHQRYKDTTMKEVTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDFDRIFEDGRETFGDK