4rxe A 2.5 BS01 3YQ A 1 D103 D107 R112 K212 Y216 D255 K269 D94 D98 R103 K203 Y207 D246 K260 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H89 D94 D98 R103 D166 K203 F242 D246 D247 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=230nM -logKd/Ki=6.64, IC50=230nM Q86C09 25815158 3001 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe A 2.5 BS02 MG A 1 D103 D107 D94 D98 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H89 D94 D98 R103 D166 K203 F242 D246 D247 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 3002 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe A 2.5 BS03 MG A 2 D103 D107 D94 D98 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H89 D94 D98 R103 D166 K203 F242 D246 D247 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 3004 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe B 2.5 BS01 3YQ B 1 L100 D103 R112 K212 Y216 D255 L92 D95 R104 K204 Y208 D247 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H90 D95 D99 R104 D167 K204 F243 D247 D248 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=230nM Q86C09 25815158 4001 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe B 2.5 BS02 MG B 1 D103 D107 D95 D99 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H90 D95 D99 R104 D167 K204 F243 D247 D248 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 4002 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe B 2.5 BS03 MG B 2 D255 D273 D247 D265 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H90 D95 D99 R104 D167 K204 F243 D247 D248 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 4003 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe B 2.5 BS04 MG B 3 D103 D107 D95 D99 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H90 D95 D99 R104 D167 K204 F243 D247 D248 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 4004 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK