4rxd A 2.0 BS01 MG A 1 D103 D107 D91 D95 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K45 H86 D91 D95 R100 D163 K200 F239 D243 D244 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 1401 MQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd A 2.0 BS02 MG A 2 D103 D107 D91 D95 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K45 H86 D91 D95 R100 D163 K200 F239 D243 D244 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 1403 MQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd A 2.0 BS03 RIS A 1 D103 R112 Q172 K212 T213 D255 K269 D91 R100 Q160 K200 T201 D243 K257 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K45 H86 D91 D95 R100 D163 K200 F239 D243 D244 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=300nM -logKd/Ki=6.52, IC50=300nM Q86C09 25815158 1404 MQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd B 2.0 BS01 MG B 1 D103 D107 D93 D97 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K202 F241 D245 D246 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 1501 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd B 2.0 BS02 MG B 2 D103 D107 D93 D97 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K202 F241 D245 D246 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 1503 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd B 2.0 BS03 RIS B 1 D103 R112 Q172 K212 T213 D255 K269 D93 R102 Q162 K202 T203 D245 K259 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K202 F241 D245 D246 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=300nM Q86C09 25815158 1504 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd C 2.0 BS01 RIS C 1 D103 R112 Q172 K212 T213 D255 K269 D93 R102 Q162 K202 T203 D245 K259 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K202 F241 D245 D246 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50=300nM -logKd/Ki=6.52, IC50=300nM Q86C09 25815158 1600 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd C 2.0 BS02 MG C 1 D103 D107 D93 D97 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K202 F241 D245 D246 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 1601 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxd C 2.0 BS03 MG C 2 D103 D107 D93 D97 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K202 F241 D245 D246 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 1603 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK