4rxc A 2.31 BS01 HRX A 1 D103 R112 Q172 K212 D92 R101 Q161 K199 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H87 D92 D96 R101 D164 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50~33uM -logKd/Ki=4.48, IC50~33uM Q86C09 25815158 401 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPRLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc A 2.31 BS02 MG A 1 D103 D107 D92 D96 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H87 D92 D96 R101 D164 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 402 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPRLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc A 2.31 BS03 MG A 2 D103 D107 D92 D96 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H87 D92 D96 R101 D164 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 403 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPRLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc A 2.31 BS04 HRX A 2 F251 Q252 D255 F238 Q239 D242 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H87 D92 D96 R101 D164 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50~33uM -logKd/Ki=4.48, IC50~33uM Q86C09 25815158 405 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPRLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc B 2.31 BS01 HRX B 1 D103 R112 Q172 Y216 D93 R102 Q162 Y203 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50~33uM -logKd/Ki=4.48, IC50~33uM Q86C09 25815158 401 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc B 2.31 BS02 MG B 1 D103 D107 D93 D97 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 402 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc B 2.31 BS03 MG B 2 D103 D107 D93 D97 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 Q86C09 25815158 403 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc B 2.31 BS04 HRX B 2 F251 Q252 D255 K269 F238 Q239 D242 K256 K47 H98 D103 D107 R112 D175 K212 F251 D255 D256 K47 H88 D93 D97 R102 D165 K199 F238 D242 D243 ? 0004161,0004337,0004659,0005737,0008299,0016740,0016765,0045337,0046872 ic50~33uM -logKd/Ki=4.48, IC50~33uM Q86C09 25815158 405 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR