4rrz A 2.569 BS01 LUR A 1 Y348 V349 L352 S353 Y385 W387 M522 G526 A527 S530 L531 Y317 V318 L321 S322 Y354 W356 M491 G495 A496 S499 L500 Q203 H207 L384 Y385 H388 G526 S530 Q172 H176 L353 Y354 H357 G495 S499 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030216,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 IC50=40nM Q05769 25825493 705 ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVWYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQ 4rrz B 2.569 BS01 LUR B 1 Y348 V349 L352 Y385 W387 M522 G526 A527 S530 L531 Y317 V318 L321 Y354 W356 M491 G495 A496 S499 L500 Q203 H207 L384 Y385 H388 G526 S530 Q172 H176 L353 Y354 H357 G495 S499 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030216,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 IC50=40nM Q05769 25825493 705 ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVWYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQ 4rrz C 2.569 BS01 LUR C 1 Y348 V349 L352 Y385 W387 M522 G526 A527 S530 L531 Y317 V318 L321 Y354 W356 M491 G495 A496 S499 L500 Q203 H207 L384 Y385 H388 G526 S530 Q172 H176 L353 Y354 H357 G495 S499 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030216,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 IC50=40nM Q05769 25825493 705 ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVWYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQ 4rrz D 2.569 BS01 LUR D 1 Y348 V349 S353 Y385 W387 M522 G526 A527 S530 L531 Y317 V318 S322 Y354 W356 M491 G495 A496 S499 L500 Q203 H207 L384 Y385 H388 G526 S530 Q172 H176 L353 Y354 H357 G495 S499 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030216,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 IC50=40nM Q05769 25825493 705 ANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVWYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQ