4rn2 A 2.39 BS01 ZN A 1 D178 H180 D267 D150 H152 D239 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 Q9BY41 25793284 401 VPVYIYSPEYVSMCDSLAKIPKRADMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQSIEYGLTEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4rn2 A 2.39 BS02 L7G A 1 H143 F152 H180 F208 Y306 H115 F124 H152 F180 Y278 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 ic50=1500nM -logKd/Ki=5.82, IC50=1500nM IC50=1491nM Q9BY41 25793284 404 VPVYIYSPEYVSMCDSLAKIPKRADMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQSIEYGLTEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4rn2 A 2.39 BS03 L7G B 1 K33 P273 Y306 K19 P245 Y278 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 ic50=1500nM -logKd/Ki=5.82, IC50=1500nM IC50=1491nM Q9BY41 25793284 404 VPVYIYSPEYVSMCDSLAKIPKRADMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQSIEYGLTEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4rn2 B 2.39 BS01 L7G A 1 P273 Y306 P253 Y286 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 ic50=1500nM IC50=1491nM Q9BY41 25793284 404 VPVYIYSPEYVSMCDSLAKIPKRADMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4rn2 B 2.39 BS02 ZN B 1 D178 H180 D267 D158 H160 D247 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 Q9BY41 25793284 401 VPVYIYSPEYVSMCDSLAKIPKRADMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV 4rn2 B 2.39 BS03 L7G B 1 Y100 H143 F152 H180 F208 Y306 Y80 H123 F132 H160 F188 Y286 3.5.1.-,3.5.1.98 0000118,0000122,0000228,0004407,0005515,0005634,0005654,0005694,0005737,0006325,0007064,0016787,0030544,0031397,0031647,0032204,0033558,0040029,0046872,0051879,0140297,0160008,0160009 ic50=1500nM IC50=1491nM Q9BY41 25793284 404 VPVYIYSPEYVSMCDSLAKIPKRADMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV