4rao A 1.871 BS01 3L7 A 1 K68 G69 D137 T138 G139 K140 T141 K165 F186 V187 R199 K68 G69 D118 T119 G120 K121 T122 K146 F167 V168 R180 E133 D134 D137 F186 R199 E114 D115 D118 F167 R180 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=1uM -logKd/Ki=6.00, Ki=1uM P00492 25494538 301 ATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSRSIPMTVDFIRLKLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYK 4rao A 1.871 BS02 MG A 1 E133 D134 E114 D115 E133 D134 D137 F186 R199 E114 D115 D118 F167 R180 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 ATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSRSIPMTVDFIRLKLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYK 4rao B 1.871 BS01 3L7 B 1 D137 T138 G139 K140 T141 K165 F186 V187 D120 T121 G122 K123 T124 K148 F167 V168 E133 D134 D137 F186 R199 E116 D117 D120 F167 R180 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=1uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rao B 1.871 BS02 MG B 1 E133 D134 E116 D117 E133 D134 D137 F186 R199 E116 D117 D120 F167 R180 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rao C 1.871 BS01 3L7 C 1 K68 G69 I135 D137 T138 G139 T141 K165 F186 V187 D193 R199 K65 G66 I121 D123 T124 G125 T127 K151 F172 V173 D179 R185 E133 D134 D137 F186 R199 E119 D120 D123 F172 R185 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=1uM -logKd/Ki=6.00, Ki=1uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rao C 1.871 BS02 MG C 1 E133 D134 E119 D120 E133 D134 D137 F186 R199 E119 D120 D123 F172 R185 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rao D 1.871 BS01 3L7 D 1 K68 G69 D137 T138 G139 T141 K165 F186 V187 D193 R199 K65 G66 D127 T128 G129 T131 K155 F176 V177 D183 R189 E133 D134 D137 F186 R199 E123 D124 D127 F176 R189 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=1uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rao D 1.871 BS02 MG D 1 E133 D134 E123 D124 E133 D134 D137 F186 R199 E123 D124 D127 F176 R189 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA