4rad A 2.0 BS01 3L5 A 1 I135 D137 T138 G139 T141 K165 F186 V187 I118 D120 T121 G122 T124 K148 F166 V167 E133 D134 D137 F186 R199 E116 D117 D120 F166 R179 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 -logKd/Ki=7.10, Ki=0.08uM P00492 25494538 301 PGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad A 2.0 BS02 MG A 1 E133 T141 E116 T124 E133 D134 D137 F186 R199 E116 D117 D120 F166 R179 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 PGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad B 2.0 BS01 3L5 B 1 I135 D137 T138 G139 T141 K165 F186 V187 I125 D127 T128 G129 T131 K155 F176 V177 E133 D134 D137 F186 R199 E123 D124 D127 F176 R189 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad B 2.0 BS02 MG B 1 E133 I135 T141 E123 I125 T131 E133 D134 D137 F186 R199 E123 D124 D127 F176 R189 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad C 2.0 BS01 3L5 C 1 K68 I135 D137 T138 G139 T141 K165 F186 V187 D193 K65 I122 D124 T125 G126 T128 K152 F173 V174 D180 E133 D134 D137 F186 R199 E120 D121 D124 F173 R186 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 -logKd/Ki=7.10, Ki=0.08uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKY 4rad C 2.0 BS02 MG C 1 E133 D134 E120 D121 E133 D134 D137 F186 R199 E120 D121 D124 F173 R186 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKY 4rad D 2.0 BS01 3L5 D 1 I135 D137 T138 G139 T141 K165 F186 V187 D193 I120 D122 T123 G124 T126 K150 F171 V172 D178 E133 D134 D137 F186 R199 E118 D119 D122 F171 R184 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad D 2.0 BS02 MG D 1 E133 D134 E118 D119 E133 D134 D137 F186 R199 E118 D119 D122 F171 R184 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad E 2.0 BS01 3L5 E 1 D134 I135 D137 T138 G139 T141 K165 F186 V187 D193 R199 D126 I127 D129 T130 G131 T133 K157 F175 V176 D182 R188 E133 D134 D137 F186 R199 E125 D126 D129 F175 R188 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad F 2.0 BS01 3L5 F 1 K102 I135 D137 T138 G139 T141 K165 F186 V187 K99 I118 D120 T121 G122 T124 K148 F166 V167 E133 D134 D137 F186 R199 E116 D117 D120 F166 R179 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSIKVIGTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad F 2.0 BS02 MG F 1 E133 I135 T141 E116 I118 T124 E133 D134 D137 F186 R199 E116 D117 D120 F166 R179 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSIKVIGTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad G 2.0 BS01 3L5 G 1 I135 D137 T138 T141 K165 F186 V187 I121 D123 T124 T127 K151 F169 V170 E133 D134 D137 F186 R199 E119 D120 D123 F169 R182 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 PGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad G 2.0 BS02 MG G 1 E133 D134 E119 D120 E133 D134 D137 F186 R199 E119 D120 D123 F169 R182 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 PGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad H 2.0 BS01 3L5 H 1 K68 D137 T138 G139 T141 K165 F186 V187 D193 R199 K66 D128 T129 G130 T132 K156 F177 V178 D184 R190 E133 D134 D137 F186 R199 E124 D125 D128 F177 R190 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad H 2.0 BS02 MG H 1 E133 D134 E124 D125 E133 D134 D137 F186 R199 E124 D125 D128 F177 R190 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 302 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA