4ra5 A 2.61 BS01 3L0 A 1 L386 G387 K388 V394 A407 M458 E459 D508 L511 D522 F664 F668 L13 G14 K15 V21 A34 M85 E86 D135 L138 D149 F291 F295 D504 K506 D508 N509 D522 T542 D131 K133 D135 N136 D149 T169 2.7.11.13 0004672,0004674,0004697,0005524,0006468 -logKd/Ki=8.40, IC50=4nM IC50=4.0nM Q04759 25254961 801 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLISH 4ra5 B 2.61 BS01 3L0 B 1 G387 K388 V394 T442 M458 E459 L461 D508 D522 G13 K14 V20 T68 M84 E85 L87 D134 D148 D504 K506 D508 N509 D522 T542 D130 K132 D134 N135 D148 T168 2.7.11.13 0004672,0004674,0004697,0005524,0006468 IC50=4.0nM Q04759 25254961 801 LKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDPRLSRALINSMDQNMFRNFSFMNPGM