4r6e A 2.2 BS01 3JD A 1 D766 H862 G863 Y889 Y896 F897 K903 S904 Y907 D106 H202 G203 Y229 Y236 F237 K243 S244 Y247 S904 Y907 E988 S244 Y247 E328 2.4.2.-,2.4.2.30 0003950 ic50=132nM -logKd/Ki=7.78, IC50=16.7nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4r6e B 2.2 BS01 3JD B 1 E763 D766 H862 G863 Y889 Y896 F897 K903 S904 Y907 E102 D105 H201 G202 Y228 Y235 F236 K242 S243 Y246 S904 Y907 E988 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 ic50=132nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4r6e C 2.2 BS01 3JD C 1 D766 H862 G863 Y889 Y896 F897 S904 Y907 D106 H202 G203 Y229 Y236 F237 S244 Y247 S904 Y907 E988 S244 Y247 E328 2.4.2.-,2.4.2.30 0003950 ic50=132nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4r6e D 2.2 BS01 3JD D 1 D766 H862 G863 G888 Y889 Y896 F897 A898 S904 Y907 D104 H200 G201 G226 Y227 Y234 F235 A236 S242 Y245 S904 Y907 E988 S242 Y245 E326 2.4.2.-,2.4.2.30 0003950 ic50=132nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK