4qw4 b 2.8 BS01 3BV b 1 T1 T20 T21 T22 R45 S46 G47 A49 S129 T1 T20 T21 T22 R45 S46 G47 A49 S129 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qw4 G 2.8 BS01 MG G 1 T8 R122 A123 M125 T7 R121 A122 M124 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005739,0005839,0006511,0010499,0019773,0043161,0051603 P21243 25599643 301 GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQ 4qw4 H 2.8 BS01 3BV H 1 T1 S20 T21 G47 A49 T1 S20 T21 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=6.95, IC50=0.113uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qw4 H 2.8 BS02 3BV N 1 H114 H116 H114 H116 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=6.95, IC50=0.113uM P25043 25599643 201 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qw4 I 2.8 BS01 MG I 1 D177 S180 D177 S180 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 25599643 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4qw4 K 2.8 BS01 3BV K 1 T1 R19 A20 T21 G47 A49 Y170 T1 R19 A20 T21 G47 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw4 K 2.8 BS02 MG K 1 A165 D168 A165 D168 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 302 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw4 L 2.8 BS01 3BV K 1 R101 H108 D126 P127 V128 R101 H108 D126 P127 V128 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 25599643 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 4qw4 N 2.8 BS01 3BV N 1 T1 T20 T21 T22 R45 S46 G47 A49 S129 T1 T20 T21 T22 R45 S46 G47 A49 S129 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qw4 V 2.8 BS01 3BV V 1 T1 S20 T21 G47 A49 T1 S20 T21 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qw4 V 2.8 BS02 MG V 1 I163 W164 D166 I163 W164 D166 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 302 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qw4 V 2.8 BS03 3BV b 1 H114 H116 H114 H116 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 201 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICD 4qw4 W 2.8 BS01 3BV V 1 D124 I126 D124 I126 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 25599643 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4qw4 Y 2.8 BS01 3BV Y 1 T1 R19 A20 T21 K33 G47 G48 A49 Y170 T1 R19 A20 T21 K33 G47 G48 A49 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw4 Y 2.8 BS02 MG Y 1 A165 D168 A169 S171 A165 D168 A169 S171 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 302 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw4 Z 2.8 BS01 3BV Y 1 R101 H108 D126 P127 R101 H108 D126 P127 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 -logKd/Ki=6.95, IC50=0.113uM P23724 25599643 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 4qw4 Z 2.8 BS02 MG Z 1 T192 V198 T192 V198 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 25599643 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD