4qw1 b 2.9 BS01 BO2 b 1 T1 T20 T21 T22 R45 G47 A49 T1 T20 T21 T22 R45 G47 A49 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qw1 G 2.9 BS01 MG G 1 T8 R122 A123 M125 T7 R121 A122 M124 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005739,0005839,0006511,0010499,0019773,0043161,0051603 P21243 25599643 301 GYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQ 4qw1 H 2.9 BS01 BO2 H 1 T1 S20 T21 Q22 G47 A49 T1 S20 T21 Q22 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=6.11, IC50=0.773uM P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 4qw1 I 2.9 BS01 MG I 1 D177 S180 D177 S180 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 25599643 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4qw1 K 2.9 BS01 BO2 K 1 T1 A20 T21 K33 M45 G47 A49 T1 A20 T21 K33 M45 G47 A49 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw1 K 2.9 BS02 MG K 1 A165 H166 D168 A169 A165 H166 D168 A169 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 302 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw1 N 2.9 BS01 BO2 N 1 T1 T20 T21 T22 R45 G47 A49 T1 T20 T21 T22 R45 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 201 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qw1 N 2.9 BS02 MG N 1 I163 D166 S169 I163 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0000502,0004175,0004298,0005515,0005634,0005737,0005829,0005839,0006508,0010499,0019774,0034515,0043161,0051603 P38624 25599643 202 TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL 4qw1 V 2.9 BS01 BO2 V 1 T1 S20 T21 Q22 G47 A49 T1 S20 T21 Q22 G47 A49 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 301 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 4qw1 V 2.9 BS02 MG V 1 I163 W164 D166 L167 I163 W164 D166 L167 T1 D17 R19 K33 G47 S129 D166 S169 T1 D17 R19 K33 G47 S129 D166 S169 3.4.25.1 0004298,0005839,0051603 P25043 25599643 302 TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEE 4qw1 W 2.9 BS01 BO2 V 1 D124 C128 D124 C128 3.4.25.1 0000502,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603,0061133 P25451 25599643 301 SDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD 4qw1 Y 2.9 BS01 BO2 Y 1 T1 A20 T21 K33 M45 G47 A49 T1 A20 T21 K33 M45 G47 A49 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 301 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw1 Y 2.9 BS02 MG Y 1 A165 D168 A169 A165 D168 A169 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25599643 302 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAVDCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qw1 Z 2.9 BS01 MG Z 1 T192 H195 I196 V198 T192 H195 I196 V198 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 25599643 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD