4qij A 2.2 BS01 1HA A 1 V57 R58 A60 F61 K95 S103 G104 G105 D106 Q107 Y115 L134 I136 W157 G161 T184 D185 S190 V44 R45 A47 F48 K82 S90 G91 G92 D93 Q94 Y102 L121 I123 W144 G148 T171 D172 S177 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij A 2.2 BS02 1HA F 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij B 2.2 BS01 1HA B 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 S190 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 S177 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij B 2.2 BS02 1HA E 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij C 2.2 BS01 1HA C 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 L134 I136 L137 W157 G161 T184 D185 S190 F191 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 L121 I123 L124 W144 G148 T171 D172 S177 F178 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij C 2.2 BS02 1HA D 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij D 2.2 BS01 1HA C 1 F299 K302 F282 K285 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij D 2.2 BS02 1HA D 1 V57 R58 K95 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 S190 F191 D192 V40 R41 K78 S86 G87 G88 D89 Q90 Y98 I119 W140 G144 T167 D168 S173 F174 D175 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij E 2.2 BS01 1HA B 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij E 2.2 BS02 1HA E 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G160 G161 T184 D185 V188 S190 F191 D192 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 L121 W141 G144 G145 T168 D169 V172 S174 F175 D176 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij F 2.2 BS01 1HA A 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij F 2.2 BS02 1HA F 1 E56 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 E40 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 L121 W141 G145 T168 D169 V172 S174 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM -logKd/Ki=5.54, Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij G 2.2 BS01 1HA G 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 V188 S190 F191 V40 R41 A43 K78 S86 G87 G88 D89 Q90 Y98 I119 W140 G144 T167 D168 V171 S173 F174 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij G 2.2 BS02 1HA K 1 F299 K302 F282 K285 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij H 2.2 BS01 1HA H 1 E56 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 V188 S190 F191 D192 E40 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 W141 G145 T168 D169 V172 S174 F175 D176 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij H 2.2 BS02 1HA J 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij I 2.2 BS01 1HA I 1 E56 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G160 G161 T184 D185 V188 S190 F191 E40 V41 R42 A44 K79 S87 G88 G89 D90 Q91 Y99 I120 L121 W141 G144 G145 T168 D169 V172 S174 F175 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij I 2.2 BS02 1HA L 1 F299 K302 F283 K286 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G89 R94 Y99 R114 H119 G145 S148 D169 S174 D176 G177 A263 Y271 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij J 2.2 BS01 1HA H 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij J 2.2 BS02 1HA J 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 F191 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 V175 S177 F178 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij K 2.2 BS01 1HA G 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij K 2.2 BS02 1HA K 1 V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 F191 D192 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 V175 S177 F178 D179 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij L 2.2 BS01 1HA I 1 F299 K302 F286 K289 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF 4qij L 2.2 BS02 1HA L 1 V57 R58 A60 S103 G104 G105 D106 Q107 Y115 I136 W157 G161 T184 D185 V188 S190 F191 V44 R45 A47 S90 G91 G92 D93 Q94 Y102 I123 W144 G148 T171 D172 V175 S177 F178 G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287 G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274 4.1.3.36 0005886,0008935,0009234,0016829,0034214 Kd=2.9uM P9WNP5 25372686 401 ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF