4qge A 2.0 BS01 35O A 1 M365 L420 Y424 A452 Q453 F456 M181 L236 Y240 A268 Q269 F272 3.1.4.35 0004114,0004115,0004117,0005737,0005783,0005794,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0046068,0046069,0046872,0047555,0048101,0048471 Ki=0.5nM -logKd/Ki=9.30, Ki=0.5nM H2QL32 25432025 601 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4qge A 2.0 BS02 ZN A 1 H256 H292 D293 D402 H72 H108 D109 D218 3.1.4.35 0004114,0004115,0004117,0005737,0005783,0005794,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0046068,0046069,0046872,0047555,0048101,0048471 H2QL32 25432025 602 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4qge B 2.0 BS01 35O B 1 M365 L420 Y424 F441 A452 Q453 F456 M181 L236 Y240 F257 A268 Q269 F272 3.1.4.35 0004114,0004115,0004117,0005737,0005783,0005794,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0046068,0046069,0046872,0047555,0048101,0048471 Ki=0.5nM H2QL32 25432025 601 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQ 4qge B 2.0 BS02 ZN B 1 H256 H292 D293 D402 H72 H108 D109 D218 3.1.4.35 0004114,0004115,0004117,0005737,0005783,0005794,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0046068,0046069,0046872,0047555,0048101,0048471 H2QL32 25432025 602 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQ