4qfs A 3.55 BS01 STU A 1 L22 G23 G25 V30 A43 I77 E94 Y95 V96 E100 E143 N144 L146 A156 D157 L14 G15 G17 V22 A35 I69 E86 Y87 V88 E92 E135 N136 L138 A148 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 P54645 25066137 601 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 4qfs A 3.55 BS02 32H A 1 K29 K31 I46 K51 D88 F90 K21 K23 I38 K43 D80 F82 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.26,2.7.11.31 0000785,0002842,0003682,0004672,0004674,0004679,0005515,0005524,0005634,0005737,0005829,0006006,0006325,0006338,0006468,0006633,0006695,0006914,0008284,0008610,0009410,0009411,0009631,0010332,0010508,0010628,0010629,0014823,0016055,0016310,0016324,0016607,0017148,0019395,0030424,0030425,0031000,0031588,0031669,0032007,0032991,0033554,0034599,0042149,0042542,0042557,0042593,0042752,0043025,0043066,0043627,0044024,0044877,0045722,0045821,0045893,0046321,0046326,0046627,0046872,0047322,0048511,0048643,0050321,0050870,0050995,0055089,0060627,0061744,0061762,0062028,0070050,0070301,0070507,0071277,0071333,0071361,0071380,0071456,0071466,0097009,0106310,0140823,1903109,1903829,1903944,1903955,1904179,1904262,1904428,1905691,1990044,2000758 -logKd/Ki=6.05, Kd=0.9uM P54645 25066137 602 GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDSHTIEFFEMCANLIKILAQ 4qfs B 3.55 BS01 32H A 1 R83 D108 V113 R5 D30 V35 ? -logKd/Ki=6.05, Kd=0.9uM P80386 25066137 602 PTVFRWTGGGKEVYLSGSFNNWSKLPLTRDQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKAPPILPPHLLQVILNKCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4qfs C 3.55 BS01 AMP C 1 H150 I203 A204 V224 S225 H297 S313 S315 D316 H123 I160 A161 V181 S182 H247 S258 S260 D261 ? 0004672,0004679,0005515,0005524,0005634,0005737,0005829,0006633,0010628,0016208,0019887,0019901,0031588,0031669,0032991,0043531,0044877,0051170 P80385 25066137 401 YTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITSLEELQIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRLKCYLHETLEAIINRLVEAEVHRLVDVVKGIVSLSDILQALV