4q3s A 2.11 BS01 MN A 1 H131 D154 D158 D262 H105 D128 D132 D236 H131 D154 H156 D158 H171 D262 D264 E307 H105 D128 H130 D132 H145 D236 D238 E281 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 401 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s A 2.11 BS02 MN A 2 D154 H156 D262 D264 D128 H130 D236 D238 H131 D154 H156 D158 H171 D262 D264 E307 H105 D128 H130 D132 H145 D236 D238 E281 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 402 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s A 2.11 BS03 X7A A 1 H131 D154 H156 D158 S167 H171 D211 D213 D262 E307 H105 D128 H130 D132 S141 H145 D185 D187 D236 E281 H131 D154 H156 D158 H171 D262 D264 E307 H105 D128 H130 D132 H145 D236 D238 E281 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.26uM -logKd/Ki=6.59, Kd=0.26uM Q6WVP6 25007099 403 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s B 2.11 BS01 MN B 1 H131 D154 D158 D262 H105 D128 D132 D236 H131 D154 H156 D158 H171 D262 D264 E307 H105 D128 H130 D132 H145 D236 D238 E281 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 401 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s B 2.11 BS02 MN B 2 D154 H156 D262 D264 D128 H130 D236 D238 H131 D154 H156 D158 H171 D262 D264 E307 H105 D128 H130 D132 H145 D236 D238 E281 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 402 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s B 2.11 BS03 X7A B 1 H131 D154 H156 D158 S167 H171 D211 D213 D262 E307 H105 D128 H130 D132 S141 H145 D185 D187 D236 E281 H131 D154 H156 D158 H171 D262 D264 E307 H105 D128 H130 D132 H145 D236 D238 E281 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.26uM Q6WVP6 25007099 403 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s C 2.11 BS01 MN C 1 H131 D154 D158 D262 H102 D125 D129 D233 H131 D154 H156 D158 H171 D262 D264 E307 H102 D125 H127 D129 H142 D233 D235 E278 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 401 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s C 2.11 BS02 MN C 2 D154 H156 D262 D264 D125 H127 D233 D235 H131 D154 H156 D158 H171 D262 D264 E307 H102 D125 H127 D129 H142 D233 D235 E278 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 402 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s C 2.11 BS03 X7A C 1 D154 H156 D158 N160 S167 H171 D211 D213 D262 E307 D125 H127 D129 N131 S138 H142 D182 D184 D233 E278 H131 D154 H156 D158 H171 D262 D264 E307 H102 D125 H127 D129 H142 D233 D235 E278 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.26uM -logKd/Ki=6.59, Kd=0.26uM Q6WVP6 25007099 403 KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ 4q3s D 2.11 BS01 MN D 1 H131 D154 D158 D262 H102 D125 D129 D233 H131 D154 H156 D158 H171 D262 D264 E307 H102 D125 H127 D129 H142 D233 D235 E278 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 401 LLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHM 4q3s D 2.11 BS02 MN D 2 D154 H156 D262 D264 D125 H127 D233 D235 H131 D154 H156 D158 H171 D262 D264 E307 H102 D125 H127 D129 H142 D233 D235 E278 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Q6WVP6 25007099 402 LLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHM 4q3s D 2.11 BS03 X7A D 1 D154 H156 D158 S167 H171 D211 D213 D262 E307 D125 H127 D129 S138 H142 D182 D184 D233 E278 H131 D154 H156 D158 H171 D262 D264 E307 H102 D125 H127 D129 H142 D233 D235 E278 3.5.3.1 0000050,0004053,0005634,0005737,0005829,0006525,0016787,0016813,0019547,0030145,0046872 Kd=0.26uM Q6WVP6 25007099 403 LLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHM