4q1d A 2.0 BS01 2Y1 A 1 E53 V55 L82 Y86 P89 Q97 D133 F137 L141 S144 Y204 E34 V36 L53 Y57 P60 Q68 D104 F108 L112 S115 Y175 E53 R128 E34 R99 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=16.6nM -logKd/Ki=7.78, Ki=16.6nM IC50=10.0nM, Ki=17nM P27707 25341194 301 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4q1d A 2.0 BS02 UDP A 1 A31 G33 K34 S35 T36 R188 R192 D241 F242 A12 G14 K15 S16 T17 R159 R163 D212 F213 E53 R128 E34 R99 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 25341194 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4q1d B 2.0 BS01 2Y1 B 1 E53 V55 Y86 P89 F96 Q97 D133 F137 S144 Y204 E34 V36 Y57 P60 F67 Q68 D104 F108 S115 Y171 E53 R128 E34 R99 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=16.6nM IC50=10.0nM, Ki=17nM P27707 25341194 301 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4q1d B 2.0 BS02 UDP B 1 A31 A32 G33 K34 S35 T36 R188 R192 D241 F242 K243 A12 A13 G14 K15 S16 T17 R155 R159 D208 F209 K210 E53 R128 E34 R99 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 25341194 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL