4q19 A 2.09 BS01 2XL A 1 E53 V55 Y86 P89 Q97 F137 Y204 E33 V35 Y55 P58 Q66 F105 Y172 E53 R128 E33 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=8.9nM -logKd/Ki=8.05, Ki=8.9nM IC50=19nM, Ki=8.9nM P27707 25341194 301 IKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4q19 A 2.09 BS02 UDP A 1 A31 A32 G33 K34 S35 T36 R188 R192 D241 A11 A12 G13 K14 S15 T16 R156 R160 D209 E53 R128 E33 R96 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 25341194 302 IKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSLTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4q19 B 2.09 BS01 2XL B 1 E53 V55 L82 Y86 P89 F96 Q97 D133 F137 E34 V36 L53 Y57 P60 F67 Q68 D103 F107 E53 R128 E34 R98 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 Ki=8.9nM IC50=19nM, Ki=8.9nM P27707 25341194 301 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNVTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL 4q19 B 2.09 BS02 UDP B 1 A31 G33 K34 S35 T36 R188 R192 D241 F242 K243 A12 G14 K15 S16 T17 R158 R162 D211 F212 K213 E53 R128 E34 R98 2.7.1.113,2.7.1.74,2.7.1.76 0004136,0004137,0004138,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006139,0006220,0008144,0009224,0016301,0016310,0019136,0042803,0043771,0106383,1901135,1901293 P27707 25341194 302 RIKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSNVTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL