4pyo A 2.1 BS01 SAH A 1 G109 Y111 S115 E133 I134 A161 S162 D184 H185 W186 G64 Y66 S70 E88 I89 A116 S117 D139 H140 W141 D184 K187 D212 N213 E242 D139 K142 D167 N168 E197 2.1.1.6 0000287,0006584,0008171,0016206 ic50~30uM -logKd/Ki=4.52, IC50~30uM P22734 25084335 301 DTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 4pyo B 2.1 BS01 SAH B 1 M83 V85 G109 Y111 S115 E133 I134 A161 S162 D184 H185 W186 M39 V41 G65 Y67 S71 E89 I90 A117 S118 D140 H141 W142 D184 K187 D212 N213 E242 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 ic50~30uM P22734 25084335 301 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 4pyo B 2.1 BS02 MG B 1 D184 D212 N213 D140 D168 N169 D184 K187 D212 N213 E242 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 25084335 302 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS