4py2 A 2.15 BS01 43E A 1 A11 I12 Y14 D51 H53 G54 M227 Y228 V229 W230 D232 I265 F268 H269 A9 I10 Y12 D49 H51 G52 M225 Y226 V227 W228 D230 I263 F266 H267 I12 H20 H23 D51 S128 D131 G150 W230 I265 I10 H18 H21 D49 S126 D129 G148 W228 I263 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 ic50=0.272uM -logKd/Ki=6.57, IC50=0.272uM Q2YQ76 27500735 601 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRY 4py2 B 2.15 BS01 43E B 1 A11 I12 Y14 D51 H53 G54 F213 M227 Y228 V229 W230 D232 I265 H269 A9 I10 Y12 D49 H51 G52 F203 M217 Y218 V219 W220 D222 I255 H259 I12 H20 H23 D51 S128 D131 G150 W230 I265 I10 H18 H21 D49 S126 D129 G140 W220 I255 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 ic50=0.272uM Q2YQ76 27500735 601 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEERYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRYVE 4py2 C 2.15 BS01 43E C 1 A11 I12 Y14 D51 H53 G54 M227 Y228 V229 W230 D232 I265 F268 H269 A9 I10 Y12 D49 H51 G52 M225 Y226 V227 W228 D230 I263 F266 H267 I12 H20 H23 D51 S128 D131 G150 W230 I265 I10 H18 H21 D49 S126 D129 G148 W228 I263 6.1.1.10 0000166,0004812,0004825,0005524,0005737,0006412,0006418,0006431 ic50=0.272uM Q2YQ76 27500735 601 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRY