4pml A 1.87 BS01 ZN A 1 C1081 H1084 C1089 C1092 C119 H122 C127 C130 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 KEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml A 1.87 BS02 3AB A 1 H1031 G1032 Y1060 F1061 K1067 S1068 Y1071 E1138 H69 G70 Y98 F99 K105 S106 Y109 E175 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=4.52, IC50>30uM Q9H2K2 25286857 1202 KEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml B 1.87 BS01 ZN B 1 C1081 H1084 C1089 C1092 C126 H129 C134 C137 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 NLYFQDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml B 1.87 BS02 3AB B 1 H1031 G1032 Y1060 F1061 A1062 S1068 Y1071 H76 G77 Y105 F106 A107 S113 Y116 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 NLYFQDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml C 1.87 BS01 3AB C 1 H1031 G1032 Y1060 F1061 S1068 Y1071 E1138 H79 G80 Y108 F109 S116 Y119 E186 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4pml C 1.87 BS02 ZN C 1 C1081 H1084 C1089 C1092 C129 H132 C137 C140 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4pml D 1.87 BS01 ZN D 1 C1081 H1084 C1089 C1092 C118 H121 C126 C129 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 EFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml D 1.87 BS02 3AB D 1 H1031 G1032 Y1060 F1061 S1068 Y1071 E1138 H68 G69 Y97 F98 S105 Y108 E175 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 EFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE