4pk6 A 3.45 BS01 HEM A 1 F163 S167 V170 F214 S263 A264 F270 R343 H346 V350 L384 F387 L388 V391 F152 S156 V159 F203 S252 A253 F259 R332 H335 V339 L354 F357 L358 V361 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 P14902 25313323 501 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG 4pk6 A 3.45 BS02 PKL A 1 Y126 C129 V130 F163 S167 F226 L234 G262 S263 A264 Y115 C118 V119 F152 S156 F215 L223 G251 S252 A253 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 IC50=1900nM P14902 25313323 502 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG 4pk6 B 3.45 BS01 HEM B 1 S167 V170 F214 S263 A264 G265 F270 R343 H346 V350 L388 V391 S156 V159 F203 S252 A253 G254 F259 R332 H335 V339 L358 V361 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 P14902 25313323 501 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG 4pk6 B 3.45 BS02 PKL B 1 Y126 C129 F163 S167 L230 R231 L234 G262 S263 A264 Y115 C118 F152 S156 L219 R220 L223 G251 S252 A253 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 IC50=1900nM P14902 25313323 502 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG