4pk5 A 2.79 BS01 HEM A 1 F163 F214 F226 S263 A264 G265 F270 R343 H346 I349 I354 F387 L388 F152 F203 F215 S252 A253 G254 F259 R332 H335 I338 I343 F357 L358 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 P14902 25313323 501 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG 4pk5 A 2.79 BS02 PKJ A 1 Y126 C129 F163 F164 S167 F226 R231 G262 S263 A264 I354 L384 Y115 C118 F152 F153 S156 F215 R220 G251 S252 A253 I343 L354 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 IC50=3000nM P14902 25313323 502 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG 4pk5 B 2.79 BS01 HEM B 1 F163 S167 F214 F226 S263 A264 G265 F270 R343 H346 I349 V350 F387 F152 S156 F203 F215 S252 A253 G254 F259 R332 H335 I338 V339 F357 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 P14902 25313323 501 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG 4pk5 B 2.79 BS02 PKJ B 1 Y126 C129 F163 S167 F226 F227 R231 G262 S263 A264 I354 Y115 C118 F152 S156 F215 F216 R220 G251 S252 A253 I343 1.13.11.52 0002376,0002666,0002678,0002830,0004833,0005737,0005829,0006569,0006954,0007565,0009055,0016702,0019441,0019805,0020037,0030485,0032421,0032496,0032693,0032735,0033555,0033754,0034276,0034354,0036269,0042098,0042130,0043065,0046006,0046872,0051213,0070233,0070234 IC50=3000nM P14902 25313323 502 SKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQGGTDLMNFLKTVRSTTEKSLLKEG