4pjt A 2.35 BS01 2YQ A 1 E763 H862 G863 G888 Y889 Y896 S904 Y907 E96 H190 G191 G216 Y217 Y224 S232 Y235 S904 Y907 E988 S232 Y235 E316 2.4.2.-,2.4.2.30 0003950 ic50=0.57nM -logKd/Ki=9.24, IC50=0.57nM Ki=1.2nM, IC50=0.570000nM, EC50=2.5nM P09874 25195882 1105 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQDSQILDLSNRFYTLIPHDFKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4pjt B 2.35 BS01 2YQ B 1 H862 G863 G888 Y889 Y896 F897 K903 S904 Y907 H186 G187 G212 Y213 Y220 F221 K227 S228 Y231 S904 Y907 E988 S228 Y231 E310 2.4.2.-,2.4.2.30 0003950 ic50=0.57nM Ki=1.2nM, IC50=0.570000nM, EC50=2.5nM P09874 25195882 1105 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSDSQILDLSNRFYTLIPHDPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASSKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4pjt C 2.35 BS01 2YQ C 1 H862 G863 G888 Y889 Y896 F897 K903 S904 Y907 H198 G199 G224 Y225 Y232 F233 K239 S240 Y243 S904 Y907 E988 S240 Y243 E324 2.4.2.-,2.4.2.30 0003950 ic50=0.57nM Ki=1.2nM, IC50=0.570000nM, EC50=2.5nM P09874 25195882 1104 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4pjt D 2.35 BS01 2YQ D 1 Q759 H862 G863 G888 Y889 Y896 F897 K903 S904 Y907 Q84 H179 G180 G205 Y206 Y213 F214 K220 S221 Y224 S904 Y907 E988 S221 Y224 E305 2.4.2.-,2.4.2.30 0003950 ic50=0.57nM Ki=1.2nM, IC50=0.570000nM, EC50=2.5nM P09874 25195882 1104 SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSLDLSNRFYTLIPHDPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNF