4p38 A 2.8 BS01 NDP A 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 G216 L217 I218 T220 T222 A223 G16 S18 K19 G20 I21 A40 R41 S42 T67 M68 N94 I96 V143 S145 Y158 K162 G191 L192 I193 T195 T197 A198 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 23088558 301 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNWDRFI 4p38 A 2.8 BS02 21T A 1 S170 Y177 Y183 G216 L217 A223 A226 S145 Y152 Y158 G191 L192 A198 A201 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=9nM P28845 23088558 302 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNWDRFI 4p38 A 2.8 BS03 21T B 1 Y280 Y284 Y255 Y259 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=9nM P28845 23088558 302 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNWDRFI 4p38 B 2.8 BS01 21T A 1 Y280 Y284 Y254 Y258 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=9nM P28845 23088558 302 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNWDRF 4p38 B 2.8 BS02 NDP B 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 H120 I121 V168 S170 Y183 K187 G216 L217 I218 T220 T222 A223 G16 S18 K19 G20 I21 A40 R41 S42 T67 M68 N94 H95 I96 V143 S145 Y158 K162 G191 L192 I193 T195 T197 A198 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 23088558 301 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNWDRF 4p38 B 2.8 BS03 21T B 1 S170 Y177 Y183 G216 L217 A226 M233 S145 Y152 Y158 G191 L192 A201 M207 S170 Y183 K187 S145 Y158 K162 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 IC50=9nM P28845 23088558 302 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPLVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSIVHMQAAPKEECALEIIKGGALRQEEVYYDSSRWTTLLIRNPSRKILEELYSTSYNWDRF