4ooe A 1.826 BS01 FOM A 1 D151 S152 A176 S177 H200 Y203 M205 S213 N218 K219 D140 S141 A165 S166 H189 Y192 M194 S202 N207 K208 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 Ki=14nM IC50=80nM, Ki=140nM, Kd=40nM P9WNS1 24825256 500 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVS 4ooe A 1.826 BS02 MN A 1 D151 E153 E222 D140 E142 E211 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 501 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVS 4ooe A 1.826 BS03 NDP A 1 G19 T21 G22 S23 I24 A46 G47 A49 H50 L104 L108 A126 K128 E129 M205 G206 N209 M267 G8 T10 G11 S12 I13 A35 G36 A38 H39 L93 L97 A115 K117 E118 M194 G195 N198 M256 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 502 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVS 4ooe B 1.826 BS01 FOM B 1 D151 S152 E153 A176 S177 H200 Y203 M205 S213 N218 K219 D140 S141 E142 A165 S166 H189 Y192 M194 S202 N207 K208 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 Ki=14nM IC50=80nM, Ki=140nM, Kd=40nM P9WNS1 24825256 500 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGM 4ooe B 1.826 BS02 MN B 1 D151 E153 E222 D140 E142 E211 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 501 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGM 4ooe B 1.826 BS03 NDP B 1 G19 T21 G22 S23 I24 A46 G47 A49 H50 A69 A103 L104 A126 N127 K128 E129 D151 M205 G206 N209 M267 G8 T10 G11 S12 I13 A35 G36 A38 H39 A58 A92 L93 A115 N116 K117 E118 D140 M194 G195 N198 M256 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 502 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGM 4ooe C 1.826 BS01 FOM C 1 D151 S152 E153 A176 S177 H200 Y203 S213 N218 K219 E222 M267 D140 S141 E142 A165 S166 H189 Y192 S202 N207 K208 E211 M256 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 Ki=14nM IC50=80nM, Ki=140nM, Kd=40nM P9WNS1 24825256 500 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4ooe C 1.826 BS02 MN C 1 D151 E153 E222 D140 E142 E211 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 501 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4ooe C 1.826 BS03 NDP C 1 G19 T21 G22 S23 I24 A46 G47 A49 H50 A69 A103 L104 A126 K128 E129 D151 M205 G206 N209 M267 G8 T10 G11 S12 I13 A35 G36 A38 H39 A58 A92 L93 A115 K117 E118 D140 M194 G195 N198 M256 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 502 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4ooe D 1.826 BS01 FOM D 1 D151 S152 E153 A176 S177 H200 Y203 M205 S213 N218 K219 M267 D140 S141 E142 A165 S166 H189 Y192 M194 S202 N207 K208 M256 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 Ki=14nM IC50=80nM, Ki=140nM, Kd=40nM P9WNS1 24825256 500 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGM 4ooe D 1.826 BS02 MN D 1 D151 E153 E222 D140 E142 E211 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 501 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGM 4ooe D 1.826 BS03 NDP D 1 G19 T21 G22 S23 I24 A46 G47 A49 H50 A69 A103 L104 A126 N127 K128 E129 M205 G206 N209 M267 G8 T10 G11 S12 I13 A35 G36 A38 H39 A58 A92 L93 A115 N116 K117 E118 M194 G195 N198 M256 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 24825256 502 RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTYSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGM