4okg A 2.06 BS01 ZN A 1 H78 H237 D241 H78 H237 D241 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 P47205 301 MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP 4okg A 2.06 BS02 2SZ A 1 M62 E77 H78 T190 F191 M194 I197 R201 G209 S210 V216 D241 H264 M62 E77 H78 T190 F191 M194 I197 R201 G209 S210 V216 D241 H264 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 -logKd/Ki=9.32, IC50=0.48nM P47205 302 MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP 4okg B 2.06 BS01 ZN B 1 H78 H237 D241 H78 H229 D233 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 P47205 301 MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP 4okg B 2.06 BS02 2SZ B 1 M62 E77 T190 F191 I197 L200 R201 A206 G209 S210 V216 D241 H264 M62 E77 T182 F183 I189 L192 R193 A198 G201 S202 V208 D233 H256 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 P47205 302 MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP