4od9 A 1.9 BS01 2RZ A 1 D33 G35 Y78 G79 S80 D32 G34 Y77 G78 S79 D33 S36 N38 W40 Y78 D32 S35 N37 W39 Y77 3.4.23.5 0004190,0006508 ic50=58nM -logKd/Ki=7.24, IC50=58nM IC50=58nM P07339 25086681 103 PIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQS 4od9 B 1.9 BS01 2RZ A 1 F126 F131 I134 Y205 I229 D231 G233 T234 M309 I311 F20 F25 I28 Y99 I123 D125 G127 T128 M203 I205 D231 T234 D125 T128 3.4.23.5 0004190,0006508 -logKd/Ki=7.24, IC50=58nM IC50=58nM P07339 25086681 103 GVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 4od9 C 1.9 BS01 2RZ D 1 D33 Y78 G79 D32 Y77 G78 D33 S36 N38 W40 Y78 D32 S35 N37 W39 Y77 3.4.23.5 0004190,0006508 IC50=58nM P07339 25086681 402 PIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQS 4od9 D 1.9 BS01 2RZ D 1 F126 F131 I134 Y205 I229 D231 G233 T234 M309 F21 F26 I29 Y100 I124 D126 G128 T129 M204 D231 T234 D126 T129 3.4.23.5 0004190,0006508 ic50=58nM IC50=58nM P07339 25086681 402 GGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA