4nvq A 2.03 BS01 2OD A 1 Y1067 A1077 D1078 D1083 L1086 F1087 D1088 F1152 Y1154 R1157 F1158 I1161 Y152 A162 D163 D168 L171 F172 D173 F233 Y235 R238 F239 I242 Y1067 Y1154 Y152 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 ic50=3.3nM -logKd/Ki=8.48, IC50=3.3nM IC50=3.3nM Q96KQ7 24900801 1201 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS 4nvq A 2.03 BS02 SAH A 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1158 F1166 C1168 M133 W135 S169 Y170 R190 F191 N193 H194 Y235 F239 F246 C248 Y1067 Y1154 Y152 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1202 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS 4nvq A 2.03 BS03 ZN A 1 C974 C987 C1017 C1021 C59 C72 C102 C106 Y1067 Y1154 Y152 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1203 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS 4nvq A 2.03 BS04 ZN A 2 C974 C976 C980 C985 C59 C61 C65 C70 Y1067 Y1154 Y152 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1204 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS 4nvq A 2.03 BS05 ZN A 3 C980 C1017 C1023 C1027 C65 C102 C108 C112 Y1067 Y1154 Y152 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1205 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS 4nvq A 2.03 BS06 ZN A 4 C1115 C1168 C1170 C1175 C196 C248 C250 C255 Y1067 Y1154 Y152 Y235 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1206 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS 4nvq B 2.03 BS01 SAH B 1 M1048 W1050 Y1085 R1109 F1110 N1112 H1113 Y1154 F1158 F1166 C1168 Q1169 M126 W128 Y163 R182 F183 N185 H186 Y227 F231 F239 C241 Q242 Y1067 Y1154 Y145 Y227 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1201 TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA 4nvq B 2.03 BS02 2OD B 1 Y1067 D1074 A1077 D1078 D1083 S1084 L1086 F1087 D1088 F1152 Y1154 R1157 F1158 I1161 Y145 D152 A155 D156 D161 S162 L164 F165 D166 F225 Y227 R230 F231 I234 Y1067 Y1154 Y145 Y227 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 ic50=3.3nM IC50=3.3nM Q96KQ7 24900801 1202 TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA 4nvq B 2.03 BS03 ZN B 1 C980 C1017 C1023 C1027 C63 C95 C101 C105 Y1067 Y1154 Y145 Y227 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1203 TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA 4nvq B 2.03 BS04 ZN B 2 C974 C976 C980 C985 C57 C59 C63 C68 Y1067 Y1154 Y145 Y227 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1204 TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA 4nvq B 2.03 BS05 ZN B 3 C974 C987 C1017 C1021 C57 C70 C95 C99 Y1067 Y1154 Y145 Y227 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1205 TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA 4nvq B 2.03 BS06 ZN B 4 C1115 C1168 C1170 C1175 C188 C241 C243 C248 Y1067 Y1154 Y145 Y227 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 24900801 1206 TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA