4nkw A 2.5 BS01 HEM A 1 R96 I112 A113 W121 R125 A302 T306 V366 I371 H373 P434 F435 R440 C442 I443 G444 R66 I82 A83 W91 R95 A263 T267 V327 I332 H334 P395 F396 R401 C403 I404 G405 T306 F435 C442 T267 F396 C403 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 25301938 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw A 2.5 BS02 PLO A 1 L105 N202 I205 G301 L75 N172 I175 G262 T306 F435 C442 T267 F396 C403 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 Kd<100nM P05093 25301938 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw B 2.5 BS01 HEM B 1 R96 I112 A113 R125 I299 A302 T306 L370 I371 H373 P434 F435 R440 C442 I443 G444 R66 I82 A83 R95 I260 A263 T267 L331 I332 H334 P395 F396 R401 C403 I404 G405 T306 F435 C442 T267 F396 C403 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 25301938 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw B 2.5 BS02 PLO B 1 D298 G301 D259 G262 T306 F435 C442 T267 F396 C403 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 Kd<100nM P05093 25301938 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw C 2.5 BS01 HEM C 1 R96 I112 A113 W121 R125 A302 T306 T307 V366 L370 H373 P434 F435 R440 C442 G444 R66 I82 A83 W91 R95 A266 T270 T271 V330 L334 H337 P398 F399 R404 C406 G408 T306 F435 C442 T270 F399 C406 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 25301938 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw C 2.5 BS02 PLO C 1 N202 T306 V482 V483 N172 T270 V446 V447 T306 F435 C442 T270 F399 C406 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 Kd<100nM P05093 25301938 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw D 2.5 BS01 HEM D 1 R96 I112 A113 R125 I299 A302 T306 T307 V366 L370 H373 P434 F435 R440 C442 I443 R66 I82 A83 R95 I263 A266 T270 T271 V330 L334 H337 P398 F399 R404 C406 I407 T306 F435 C442 T270 F399 C406 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 25301938 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkw D 2.5 BS02 PLO D 1 L105 N202 I206 I371 V482 V483 L75 N172 I176 I335 V446 V447 T306 F435 C442 T270 F399 C406 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 Kd<100nM P05093 25301938 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ