4nct A 2.597 BS01 2K2 A 1 I165 G166 V173 A186 M240 E291 D307 I32 G33 V40 A53 M107 E158 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=7.55, Ki=28.4nM Kd=100nM Q13627 25945585 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 4nct B 2.597 BS01 2K2 B 1 I165 V173 A186 K188 L241 E291 L294 D307 I33 V41 A54 K56 L103 E153 L156 D169 D287 K289 N292 D307 S324 D149 K151 N154 D169 S186 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Kd=100nM Q13627 25945585 501 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 4nct C 2.597 BS01 2K2 C 1 I165 V173 A186 K188 M240 E291 V306 D307 I32 V40 A53 K55 M107 E158 V173 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Kd=100nM Q13627 25945585 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 4nct D 2.597 BS01 2K2 D 1 I165 V173 A186 K188 M240 L241 E291 L294 I32 V40 A53 K55 M107 L108 E158 L161 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Kd=100nM Q13627 25945585 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKYKPPGTRKLHNILGVETGGPGGTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK