4n76 A 2.89 BS01 dna C 0 A170 R172 I173 L279 L281 R286 M413 W415 K422 Q433 I434 N436 H445 R446 N449 K457 R580 R611 T613 P614 R615 P650 R651 H657 R661 V685 A168 R170 I171 L235 L237 R242 M369 W371 K378 Q389 I390 N392 H401 R402 N405 K413 R536 R567 T569 P570 R571 P606 R607 H613 R617 V641 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 1 ~ 10 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNALPGGLSLLDYHASKGRLQGREGGHLTGLLVPVLTLEDSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 A 2.89 BS02 dna D 0 L267 S276 S328 K329 H445 G481 K575 D590 V606 R608 F610 F647 F649 K664 L229 S232 S284 K285 H401 G437 K531 D546 V562 R564 F566 F603 F605 K620 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 10 ~ 19 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNALPGGLSLLDYHASKGRLQGREGGHLTGLLVPVLTLEDSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 A 2.89 BS03 DT B 1 P37 G38 R39 P35 G36 R37 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 704 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNALPGGLSLLDYHASKGRLQGREGGHLTGLLVPVLTLEDSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 B 2.89 BS01 dna E 0 A170 Y171 R172 I173 R192 R194 L265 S280 L281 R286 P412 M413 W415 K422 Q433 I434 N436 H445 R446 N449 K457 R580 R611 T613 P614 R615 A644 P650 R651 H657 R661 V685 A164 Y165 R166 I167 R186 R188 L252 S262 L263 R268 P394 M395 W397 K404 Q415 I416 N418 H427 R428 N431 K439 R562 R593 T595 P596 R597 A626 P632 R633 H639 R643 V667 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 1 ~ 11 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 B 2.89 BS02 dna F 0 E268 S328 K329 H445 G481 K575 D590 V606 R608 F647 F649 K664 E255 S310 K311 H427 G463 K557 D572 V588 R590 F629 F631 K646 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 10 ~ 19 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 B 2.89 BS03 MN B 1 D478 A479 D546 D460 A461 D528 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 702 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 B 2.89 BS04 MN B 2 D478 D546 D660 D460 D528 D642 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 703 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV 4n76 B 2.89 BS05 DT B 1 Y197 L217 P218 Y226 H227 R232 P255 H256 Y191 L209 P210 Y218 H219 R224 P242 H243 3.1.24.- 0003676,0003677,0003723,0004519,0004520,0006260,0030145,0044355,0046872 Q746M7 24374628 704 HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLRLEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKPIPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV