4n4s A 2.2 BS01 2H1 A 1 V37 A50 K52 I54 I82 I101 M106 L154 L164 V30 A43 K45 I47 I75 I94 M99 L147 L157 D147 K149 S151 N152 D165 T188 D140 K142 S144 N145 D158 T174 2.7.11.24 0000165,0001784,0003690,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005769,0005770,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006974,0007166,0007507,0008284,0008286,0008353,0009636,0009887,0010759,0014032,0014044,0014069,0015966,0016020,0016301,0016310,0018105,0018107,0019233,0019858,0019901,0019902,0030278,0030335,0030424,0030521,0030641,0030878,0031143,0031435,0031647,0031663,0032212,0032355,0032496,0032839,0032872,0032991,0033574,0033598,0034198,0034614,0035094,0035556,0036120,0038127,0038133,0042220,0042307,0042473,0042542,0042552,0042802,0043204,0043330,0043401,0043627,0044849,0045596,0045727,0045893,0046697,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060045,0060291,0060324,0060425,0060440,0060716,0061308,0061431,0070161,0070371,0070849,0071276,0071320,0071356,0071364,0071380,0072584,0072686,0090170,0097237,0097305,0106310,0120041,1904355,1990314,2000641 -logKd/Ki=6.88, Ki=133nM P63086 24704509 401 GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVADLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKILDFGLARVADPDTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY 4n4s B 2.2 BS01 2H1 B 1 V37 A50 K52 I54 L73 I82 I101 A103 M106 L154 V30 A43 K45 I47 L66 I75 I94 A96 M99 L147 D147 K149 S151 N152 D165 T188 D140 K142 S144 N145 D158 T169 2.7.11.24 0000165,0001784,0003690,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005769,0005770,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006974,0007166,0007507,0008284,0008286,0008353,0009636,0009887,0010759,0014032,0014044,0014069,0015966,0016020,0016301,0016310,0018105,0018107,0019233,0019858,0019901,0019902,0030278,0030335,0030424,0030521,0030641,0030878,0031143,0031435,0031647,0031663,0032212,0032355,0032496,0032839,0032872,0032991,0033574,0033598,0034198,0034614,0035094,0035556,0036120,0038127,0038133,0042220,0042307,0042473,0042542,0042552,0042802,0043204,0043330,0043401,0043627,0044849,0045596,0045727,0045893,0046697,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060045,0060291,0060324,0060425,0060440,0060716,0061308,0061431,0070161,0070371,0070849,0071276,0071320,0071356,0071364,0071380,0072584,0072686,0090170,0097237,0097305,0106310,0120041,1904355,1990314,2000641 P63086 24704509 401 GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVADLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKILDFGLARVADPATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY