4mq2 A 2.8 BS01 2C4 A 1 F170 K188 F238 M240 L241 S242 Y243 L294 V306 D307 F35 K53 F103 M105 L106 S107 Y108 L159 V171 D172 D287 K289 N292 D307 S324 D152 K154 N157 D172 S189 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=7.01, IC50=0.097uM IC50=97nM Q13627 24239188 501 YNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 4mq2 B 2.8 BS01 2C4 B 1 K188 F238 M240 L241 Y243 V306 D307 K54 F102 M104 L105 Y107 V170 D171 D287 K289 N292 D307 S324 D151 K153 N156 D171 S188 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=97nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 4mq2 C 2.8 BS01 2C4 C 1 I165 F170 V173 F238 M240 L241 S242 L294 V306 D307 I31 F36 V39 F102 M104 L105 S106 L158 V170 D171 D287 K289 N292 D307 S324 D151 K153 N156 D171 S188 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=97nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 4mq2 D 2.8 BS01 2C4 D 1 I165 F170 K188 F238 L241 S242 Y243 L294 V306 D307 I31 F36 K54 F104 L107 S108 Y109 L160 V172 D173 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=97nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKWNLKKTKKREYKPPGTRKLHNILGVETGGPHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK