4mq1 A 2.35 BS01 2C3 A 1 I165 G166 K167 G168 F170 G171 V173 K188 F238 M240 L241 S242 N292 L294 V306 D307 I31 G32 K33 G34 F36 G37 V39 K54 F104 M106 L107 S108 N158 L160 V172 D173 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=7.92, IC50=0.012uM IC50=12nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 4mq1 B 2.35 BS01 2C3 B 1 I165 K167 G168 F170 G171 V173 K188 F238 M240 L241 S242 Y243 N292 L294 V306 D307 I31 K33 G34 F36 G37 V39 K54 F104 M106 L107 S108 Y109 N158 L160 V172 D173 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=12nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 4mq1 C 2.35 BS01 2C3 C 1 I165 K167 G168 G171 V173 K188 F238 M240 L241 S242 Y243 N292 L294 V306 D307 I31 K33 G34 G37 V39 K54 F101 M103 L104 S105 Y106 N155 L157 V169 D170 D287 K289 N292 D307 S324 D150 K152 N155 D170 S187 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=12nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 4mq1 D 2.35 BS01 2C3 D 1 I165 K167 G168 F170 G171 V173 K188 F238 M240 L241 S242 N292 L294 V306 D307 I31 K33 G34 F36 G37 V39 K54 F104 M106 L107 S108 N158 L160 V172 D173 D287 K289 N292 D307 S324 D153 K155 N158 D173 S190 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 IC50=12nM Q13627 24239188 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKWNLKKTKKREYKPPGTRKLHNILGVETGGPGGRRAGESHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF