4mne A 2.8483 BS01 ACP A 1 G75 A76 G77 N78 V82 A95 K97 M143 M146 S150 Q153 K192 S194 L197 G13 A14 G15 N16 V20 A33 K35 M81 M84 S88 Q91 K130 S132 L135 D190 K192 S194 N195 D208 D217 T226 D128 K130 S132 N133 D146 D155 T164 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 901 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 4mne A 2.8483 BS02 MG A 1 N195 D208 N133 D146 D190 K192 S194 N195 D208 D217 T226 D128 K130 S132 N133 D146 D155 T164 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 902 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 4mne A 2.8483 BS03 573 A 1 G80 K97 L115 V127 I141 M143 C207 D208 F209 G210 V211 S212 L215 G18 K35 L53 V65 I79 M81 C145 D146 F147 G148 V149 S150 L153 D190 K192 S194 N195 D208 D217 T226 D128 K130 S132 N133 D146 D155 T164 2.7.12.2 0004672,0005524,0006468 EC50=7.2nM, IC50=35nM Q02750 25155755 903 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 4mne D 2.8483 BS01 ACP D 1 L74 G75 A76 G77 V82 A95 K97 M143 M146 S150 Q153 K192 S194 L197 L9 G10 A11 G12 V17 A30 K32 M78 M81 S85 Q88 K127 S129 L132 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 901 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4mne D 2.8483 BS02 MG D 1 N195 D208 N130 D143 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 902 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4mne D 2.8483 BS03 573 D 1 G80 K97 V127 I141 D208 F209 G210 V211 S212 L215 I216 M219 G15 K32 V62 I76 D143 F144 G145 V146 S147 L150 I151 M154 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 EC50=7.2nM, IC50=35nM Q02750 25155755 903 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 4mne E 2.8483 BS01 ACP E 1 L74 G77 N78 V82 A95 K97 M143 M146 S150 Q153 K192 S194 L197 L13 G16 N17 V21 A34 K36 M82 M85 S89 Q92 K131 S133 L136 D190 K192 S194 N195 D208 D217 T226 D129 K131 S133 N134 D147 D156 T165 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 901 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 4mne E 2.8483 BS02 MG E 1 N195 D208 N134 D147 D190 K192 S194 N195 D208 D217 T226 D129 K131 S133 N134 D147 D156 T165 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 902 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 4mne E 2.8483 BS03 573 E 1 K97 V127 I141 D208 F209 G210 V211 S212 L215 I216 M219 K36 V66 I80 D147 F148 G149 V150 S151 L154 I155 M158 D190 K192 S194 N195 D208 D217 T226 D129 K131 S133 N134 D147 D156 T165 2.7.12.2 0004672,0005524,0006468 EC50=7.2nM, IC50=35nM Q02750 25155755 903 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 4mne H 2.8483 BS01 ACP H 1 L74 G75 A76 G77 G80 A95 K97 M143 M146 S150 Q153 K192 S194 L197 L9 G10 A11 G12 G15 A30 K32 M78 M81 S85 Q88 K127 S129 L132 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 901 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 4mne H 2.8483 BS02 MG H 1 N195 D208 N130 D143 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 Q02750 25155755 902 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 4mne H 2.8483 BS03 573 H 1 K97 L118 V127 I141 M143 D208 F209 G210 V211 S212 L215 M219 K32 L53 V62 I76 M78 D143 F144 G145 V146 S147 L150 M154 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 EC50=7.2nM, IC50=35nM Q02750 25155755 903 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 4mne H 2.8483 BS04 573 H 2 H87 L92 M94 H119 Y130 H22 L27 M29 H54 Y65 D190 K192 S194 N195 D208 D217 T226 D125 K127 S129 N130 D143 D152 T161 2.7.12.2 0004672,0005524,0006468 EC50=7.2nM, IC50=35nM Q02750 25155755 904 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG